KEGG   Mus musculus (house mouse): 19713
Entry
19713             CDS       T01002                                 
Symbol
Ret, PTC, RET51, RET9, c-Ret
Name
(RefSeq) ret proto-oncogene
  KO
K05126  proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu04010  MAPK signaling pathway
mmu04020  Calcium signaling pathway
mmu04151  PI3K-Akt signaling pathway
mmu05200  Pathways in cancer
mmu05216  Thyroid cancer
mmu05223  Non-small cell lung cancer
mmu05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    19713 (Ret)
   04020 Calcium signaling pathway
    19713 (Ret)
   04151 PI3K-Akt signaling pathway
    19713 (Ret)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    19713 (Ret)
   05230 Central carbon metabolism in cancer
    19713 (Ret)
  09162 Cancer: specific types
   05216 Thyroid cancer
    19713 (Ret)
   05223 Non-small cell lung cancer
    19713 (Ret)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    19713 (Ret)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     19713 (Ret)
Protein kinases [BR:mmu01001]
 Receptor tyrosine kinases (RTK)
  RET family
   19713 (Ret)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr RET_CLD1 RET_CLD4 RET_CLD3 Pkinase Cadherin RIO1 Pkinase_fungal Haspin_kinase ABC1
Other DBs
NCBI-GeneID: 19713
NCBI-ProteinID: NP_033076
MGI: 97902
Ensembl: ENSMUSG00000030110
UniProt: P35546
Structure
Position
6:complement(118128709..118174705)
AA seq 1115 aa
MAKATSGAAGLGLKLILLLPLLGEAPLGLYFSRDAYWERLYVDQPAGTPLLYVHALRDAP
GEVPSFRLGQHLYGVYRTRLHENDWIRINETTGLLYLNQSLDHSSWEQLSIRNGGFPLLT
IFLQVFLGSTAQREGECHWPGCTRVYFSFINDTFPNCSSFKAQDLCIPETAVSFRVRENR
PPGTFYHFHMLPVQFLCPNISVKYSLLGGDSLPFRCDPDCLEVSTRWALDRELREKYVLE
ALCIVAGPGANKETVTLSFPVTVYDEDDSAPTFSGGVGTASAVVEFKRKEGTVVATLQVF
DADVVPASGELVRRYTNTLLSGDSWAQQTFRVEHSPIETLVQVNNNSVRATMHNYKLILN
RSLSISESRVLQLAVLVNDSDFQGPGAGGILVLHFNVSVLPVTLNLPRAYSFPVNKRARR
YAQIGKVCVENCQEFSGVSIQYKLQPSSINCTALGVVTSPEDTSGTLFVNDTEALRRPEC
TKLQYTVVATDRQTRRQTQASLVVTVEGTSITEEVGCPKSCAVNKRRPECEECGGLGSPT
GRCEWRQGDGKGITRNFSTCSPSTRTCPDGHCDAVESRDANICPQDCLRADIVGGHERGE
RQGIKAGYGICNCFPDEKKCFCEPEDSQGPLCDALCRTIITAALFSLIISILLSIFCVCH
HHKHGHKPPIASAEMTFCRPAQGFPISYSSSGTRRPSLDSTENQVPVDSFKIPEDPKWEF
PRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLL
KQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSRKIGPAYVSGGGSRNSSSLD
HPDERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV
YEEDSYVKKSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPER
LFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKSRDYLDLA
ASTPSDSLLYDDGLSEEETPLVDCNNAPLPRSLPSTWIENKLYGMSDPNWPGESPVPLTR
ADGTSTGFPRYANDSVYANWMVSPSAAKLMDTFDS
NT seq 3348 nt   +upstreamnt  +downstreamnt
atggcgaaagcgacgtccggcgccgcagggctggggctgaagctgattttgctcctgccg
ctgctaggagaagccccactgggcctctatttctcaagggatgcttactgggagaggctg
tatgtagaccagccagctggcacacctctgctctatgtccatgccctacgggatgcccct
ggagaagtgccgagcttccgcctgggccagcatctctatggcgtctaccgtacacggctg
catgagaatgactggatccgcatcaatgagactactggccttctctacctcaatcagagc
ctggaccacagttcctgggaacagctcagcatccgcaatggtggtttccccctgctcacc
atcttcctccaggtctttctggggtccacagcccagagagagggagaatgccattggcca
ggctgtacccgtgtgtacttctccttcatcaacgacaccttcccaaattgtagctccttc
aaagcccaggatctctgcatcccagagacagccgtgtccttccgagtcagggagaacagg
cctcctggcaccttctaccacttccacatgttacccgtgcagttcctttgtcccaacatc
agtgtgaagtacagtctcttaggaggggatagtctgcccttccgttgtgacccagactgc
ctggaggtgagcactcgctgggccctggatcgagagctccgggagaagtatgtgctggag
gctttgtgcatagtggcaggccctggtgccaacaaagagacggtgactctgtccttccca
gtgacagtgtatgatgaggacgactcggcgcccaccttctctggaggtgtgggcactgcc
agcgcggtggtggagtttaagcggaaggagggcactgtggtggccaccctgcaggtgttc
gatgcagatgtggtgccagcgtctggggagctggtgagacggtacacaaacacactcctc
tcaggggactcctgggcccagcagaccttccgggtggagcattcgcccatcgagaccttg
gtccaggtcaacaacaactccgttcgggcaaccatgcacaattacaagctgattctcaac
aggagcctgtctatctcagagagccgagtcctgcagctcgcggtcctggtcaacgactca
gacttccaggggcctggggcaggtggtatcctcgtcctccatttcaacgtgtctgtactg
cccgtcaccctgaacctacccagggcctactccttcccagtgaataagagggcccgccgc
tatgcccagatcgggaaagtctgtgtggaaaactgccaggagttcagcggtgtctccatc
cagtacaagctgcagccttccagcatcaactgcactgccctaggtgtggtcacctcaccc
gaggacacctcggggaccctatttgtaaatgacacagaggccctgcggcgacctgagtgc
accaagcttcagtacacggtggtagccactgaccggcagacccgcagacagacccaggct
tcgctagtggtcactgtggaggggacatccattactgaagaagtaggctgccccaagtcc
tgtgcagtaaacaagaggcgccccgagtgtgaggaatgtggtggcctgggttctccaact
ggcaggtgcgagtggcgccagggagatggtaaagggatcaccaggaacttctccacctgc
tcccccagtaccaggacctgccccgacggccactgtgatgctgtggagagccgggatgcc
aacatttgcccccaggactgtctccgtgccgacattgttggaggacacgagcgaggggag
cgccagggcattaaagcaggctacggcatctgcaactgtttccctgatgagaagaaatgc
ttctgcgagccagaggacagccagggcccactgtgtgatgcgctgtgccgcacgatcatc
acagctgccctcttctcccttatcatctccatcctgctgtccatcttctgtgtctgccac
caccacaagcatgggcacaagccgcccattgcatcagcggaaatgaccttctgccggccg
gcccagggcttcccaatcagttattcctcctcaggcacccgccggccctcactggattcc
acggagaaccaggttcctgtggactctttcaagatcccggaggatccaaagtgggaattt
cctcggaagaacttagttcttgggaaaactctgggagaaggcgagtttggaaaagttgtc
aaggccacagccttccgtctgaaaggccgggcaggatacaccacagtggctgtgaaaatg
ctgaaagaaaacgcctcccagagtgagttacgagacctgctgtctgagttcaaccttctg
aaacaagtcaaccatccacatgtcatcaagttgtatggggcctgcagccaggatgggcca
cttcttctcattgtggagtatgccaagtatggctccctgcggggattcctccgtgacagc
cgcaagattgggcctgcctatgtgagcggtggaggcagccgcaactccagctcgctggac
cacccagatgaaagggtactgaccatgggtgacctcatctccttcgcctggcagatctcg
aggggtatgcagtacttggcagaaatgaagcttgtacatcgggacttagctgccaggaac
atcttggtggctgagggacggaagatgaagatttccgactttgggctgtcccgagatgtt
tatgaggaagattcctatgtgaagaaaagcaagggccggattcccgtcaagtggatggca
attgagtcccttttcgatcacatctatactactcaaagtgatgtgtggtcctttggagtg
ctgctctgggagattgtgaccctgggaggcaacccctaccctggaattcctcctgaacga
ctcttcaaccttctgaagacaggccacaggatggagaggccagacaactgcagcgaggaa
atgtaccgtctgatgctgcagtgctggaagcaggagccagacaagaggccagtgtttgct
gacatcagcaaggatctggagaagatgatggtcaagagcagagactacttggacctggct
gcatccacaccttcggactcactgctgtatgacgatgggctctcagaagaggagacaccc
ctggtggactgtaacaatgctcccctcccgcgctccctcccttccacatggattgaaaac
aaactctatggcatgtcagacccgaactggcctggagagagtcctgtaccactcacgaga
gccgatggcactagcactgggttcccaagatatgcaaatgatagtgtatatgctaactgg
atggtttcaccctcagcggcaaaattaatggacacatttgatagctaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (7)   
   KEGG PATHWAY (7)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (42)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (35)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (18)   
   RefSeq(nuc) (2)   
   GenBank (8)   
   EMBL (8)   
3D Structure (1)   
   PDB (1)   
Protein domain (10)   
   Pfam (10)   
All databases (87)   

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